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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospectivecohort study

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: In this multi-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospectivecohort study

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 752-759 doi: 10.1007/s11684-020-0813-6

Abstract: This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/criticalIn this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who

Keywords： COVID-19     CHM     mortality     a retrospective cohort study    

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fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant---a Chinese retrospectivecohort study among 148 cases

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract:

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 156-164 doi: 10.1007/s11684-022-0932-3

Abstract: We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults. A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included. Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory. Participants with systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary zinc intake and new-onset hypertension followed a J-shape (P for non-linearity < 0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake (per mg/day: hazard ratio (HR) 0.93; 95% confidence interval (CI) 0.88–0.98) in participants with zinc intake < 10.9 mg/day, and increased with the increment of zinc intake (per mg/day: HR 1.14; 95% CI 1.11–1.16) in participants with zinc intake ≥ 10.9 mg/day. In conclusion, there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults, with an inflection point at about 10.9 mg/day.

Keywords： dietary zinc intake     new-onset hypertension     general population     CHNS    

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Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients

Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 62-67 doi: 10.1007/s11684-017-0498-7

Abstract: This study investigated the clinical manifestations, laboratory findings, and treatment of patients with

Keywords： aortic aneurysm     disseminated intravascular coagulation     anticoagulation therapy    

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prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospectivestudy of 251 cases

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract: Our study confirms the efficacy of surgery followed by platinum-based chemotherapy for EOC.

Keywords： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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Association of maternal depression with dietary intake, growth, and development of preterm infants: a cohortstudy in Beijing, China

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 533-541 doi: 10.1007/s11684-017-0591-y

Abstract:

This study aimed to explore the association of maternal depression with nutrient intake, growth, andA cohort study of 201 infants was conducted in Beijing.

Keywords： maternal depression     preterm     infant     nutrition     growth     development    

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and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019

Frontiers of Medicine doi: 10.1007/s11684-023-1014-x

Abstract: This cohort study was performed to explore the influence of intensive care unit (ICU) quality on in-hospitalThe study involved all V-V ECMO-supported patients in 318 of 1700 tertiary hospitals from 2017 to 2019Meanwhile, the V-V ECMO center volume was a protective factor (cutoff of ≥ 50 cases within the 3-year study

Keywords： veno-venous extracorporeal membrane oxygenation     in-hospital mortality     high-volume centers     quality control     intensive care unit capacity parameters    

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Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 191-196 doi: 10.1007/s11684-009-0026-5

Abstract: This retrospective study was performed to compare the outcome of thoracoabdominal incision flank incisionA case retrospective analysis assessing operation time, perioperative hemorrhage volume, size of tumor

Keywords： surgery     renal tumors     nephrectomy    

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infections among diarrheal outpatients in Shanghai: a retrospective case study

Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 98-103 doi: 10.1007/s11684-018-0614-3

Abstract: This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients

Keywords： Cyclospora cayetanensis     outpatients with diarrhea     stool specimens     18S rRNA gene    

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fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohortstudy

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuria in a community-based study

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score     brachial-ankle pulse wave velocity     albuminuria    

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Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 116-124 doi: 10.1007/s11684-019-0732-6

Abstract: Meigs’ syndrome (MS), a rare complication of benign ovarian tumors, is easily misdiagnosed as ovarian cancer (OC). We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018. Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma (OTF) and healthy control groups (all <0.05). However, the serum HE4 levels were lower in the MS group than in the OC group ( <0.001). A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups (all <0.05). However, these variables were higher in the MS group than in the OC group (both <0.05). The neutrophil-to-lymphocyte ratio (NLR) was also significantly lower, whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group (both <0.05). The NLR, platelet-to-lymphocyte ratio, and systemic immune index were significantly higher in the MS group than in the OTF and control groups (all <0.05). The hypoxia-inducible factor-1 mRNA levels were also significantly higher, whereas the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4 T cells obtained preoperatively in a patient with MS than those in patients with OTF, patients with OC, and controls (all <0.05). The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS ( <0.001). These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.

Keywords： Meigs’ syndrome     ovarian thecoma-fibroma     NLR (neutrophil to lymphocyte ratio)     CD4+ T cells     glucose metabolism    

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Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management Cohortstudy

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1684-2

Abstract:

● This study explored the long-term association by double robust

Keywords： Air pollution     Cerebrovascular disease     Incidence     Long-term exposure     Doubly robust additive model    

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Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohortstudy

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 802-810 doi: 10.1007/s11684-019-0723-7

Abstract: This study aimed to investigate this association in a community-dwelling population aged≥40 years in

Keywords： incident diabetes     prospective study     uric acid    

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of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohortstudy

Frontiers of Medicine   Pages 867-877 doi: 10.1007/s11684-023-0995-9

Abstract: Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease, and diabetes) with healthy individuals using a Cox-proportional hazard model. In July–September 2021, a total of 10 548 people (comorbidities, 2143; healthy, 8405) receiving the complete primary series of vaccination with Sinopharm/BBIBP in Bangkok, Thailand were prospectively followed for SARS-CoV-2 infection through text messaging and telephone interviewing for 6 months. A total of 295 infections from 284 participants were found. HRs (95% CI) of individuals with any comorbidities did not increase (unadjusted, 1.02 (0.77–1.36), P = 0.89; adjusted, 1.04 (0.78–1.38), P = 0.81). HRs significantly increased in the subgroup of autoimmune diseases (unadjusted, 2.64 (1.09–6.38), P = 0.032; adjusted, 4.45 (1.83–10.83), P = 0.001) but not in cardiovascular disease, chronic lung disease, or diabetes. The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with any comorbidities vs. healthy individuals. However, the protection appeared lower in the subgroup of autoimmune diseases, which may reflect suboptimal immune responses among these people.

Keywords： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

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Title Author Date Type Operation

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospectivecohort study

Journal Article

herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospectivecohort study

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Journal Article

fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant---a Chinese retrospectivecohort study among 148 cases

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study

Journal Article

Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients

Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen

Journal Article

prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospectivestudy of 251 cases

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Association of maternal depression with dietary intake, growth, and development of preterm infants: a cohortstudy in Beijing, China

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

Journal Article

and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019

Journal Article

Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Journal Article

infections among diarrheal outpatients in Shanghai: a retrospective case study

Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen

Journal Article

fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohortstudy

Journal Article

Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Journal Article

Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management Cohortstudy

Journal Article

Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohortstudy

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

Journal Article

of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohortstudy

Journal Article